产品货号:
Z24999
中文名称:
RALA抗体
英文名称:
Anti-RALA Antibody
产品规格:
50μl|100μl|150μl
发货周期:
1~3天
产品价格:
询价
抗体名称 | Anti-RALA Antibody |
指标别名 | RAL;RALA;Ras related protein Ral A |
克隆性 | Polyclonal |
检验物种 | human,mouse,rat |
应用范围 | WB |
基因名称 | RALA |
抗体来源 | Rabbit |
抗体类型 | IgG |
免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human RALA (165-203aa DKVFFDLMREIRARKMEDSKEKNGKKKRKSLAKRIRERC),identical to the related mouse and rat sequences. |
实际分子量 | 24KD |
成分 | 500μg/mL antibody with PBS,0.02% NaN3,1mg BSA and 50% glycerol. |
纯化方式 | Immunogen affinity purified. |
浓度 | 500μg/mL |
产品形态 | 溶液 |
保存条件 | 12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
背景资料 | Ras-related protein Ral-A (RalA) is a protein that in humans is encoded by the RALA gene on chromosome 7.This protein is one of two isoforms of the Ral protein,the other being RalB,and part of the Ras GTPase family.As a Ras GTPase,RalA functions as a molecular switch that becomes active when bound to GTP and inactive when bound to GDP.It can be activated by RalGEFs and,in turn,activate effectors in signal transduction pathways leading to biological outcomes.Additionally,Ral proteins have been associated with the progression of several cancers,including bladder cancer and prostate cancer.While the above functions appear to be shared between the two Ral isoforms,their differential subcellular localizations result in their differing involvement in certain biological processes.In particular,RalA is more involved in anchorage-independent cell growth,vesicle trafficking,and cytoskeletal organization.Moreover,RalA specifically interacts with Exo84 and Sec5 to regulate transport of membrane proteins in polarized epithelial cells and GLUT4 to the plasma membrane,as well as mitochondrial fission for cell division. |
Uniprot ID | P11233 |
推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
基因名全称 | v-ral simian leukemia viral oncogene homolog A (ras related) |
蛋白名全称 | Ras-related protein Ral-A |
推荐稀释比 | Western blot(WB) 1:500~2000 |
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